If you consider yourself a power Twitter user and you use a Mac, I strongly recommend looking at YoruFukurou. I’ve been using it exclusively for the last few days and it has made using Twitter much more manageable. In addition to the usual ability to support searches and lists, it can filter my timeline in real-time by users, keywords, and/or regular expressions into their own tab, which is particularly useful when trying to separate the wheat from the chaff in fast-moving breaking news. It integrates extremely well with Growl (which TweetDeck can’t do in either the AIR or the HTML5 versions) and is a Mac-native client which sips memory and CPU. The only dings against YoruFukurou: No support for multiple windows (recently re-added to Twitter for Mac) and no identi.ca/StatusNet support (which, admittedly, is kind of an edge case but I still don’t know why more developers don’t implement support for this, as I really want to use rockin’ clients with a more open network). I’d also like to see it log my favorites and retweets in my Mentions tab as TweetDeck does. Other than that, this has become my client of choice for now — and I suspect it will be for a while. Incredibly, it is free in the Mac App Store and available as a standalone file for those not Mac App Store-inclined.